Ivanov Pavel Igorevich

Neurosurgeon, M.D., Ph.D.
Head of the Department of Neuro-Oncology and Radiosurgery
Member of Leksell Gamma Knife Society (LGKS), European Society for Stereotactic and Functional Neurosurgery (ESSFN)
Member of Educational Committee of the International Stereotactic Radiosurgery Society (ISRS)
Board Member of the Russian Radiosurgery and Stereotactic Radiotherapy Society.

Pavel Ivanov began his professional career as a general neurosurgeon in the fields of acute head trauma and brain tumor surgery. He completed his PhD on the topic of surgery for skull base meningiomas with extracranial extension. He has always been interested in stereotaxy and implemented in clinical practice brain biopsies using Laitinen and Leksell stereotactic systems. In the early 2000s, he received state-of-the-art training in stereotaxy from Professor Marwan Hariz at Umea University. In 2005 he transitioned into radiosurgery and upon the kind invitation of Professor Kintomo Takakura spent four months training at Tokyo Women's Medical University. There he studied Gamma Knife radiosurgery under Professor Motohiro Hayashi, an outstanding radiosurgeon, whom he continues to regard as his mentor. After that he headed the new Department of Radiosurgery in Saint Petersburg, where the second Leksell Gamma Knife in Russia was installed in 2007. Under his leadership, the Department of Radiosurgery has performed more than fifteen thousand radiosurgical operations, ranging from benign and malignant brain tumors to functional neurosurgery and ocular diseases. Two years after opening the Department was equipped with a CyberKnife and TrueBeam STx, which expanded the possibilities of using high-dose stereotactic irradiation. PET/ CT with C-11 Methionine was another valuable addition to the Department’s facilities. Since then the activity of the Department headed by Dr. Ivanov has included hypofractionation of large brain metastases and high-grade glioma recurrences based on sophisticated metabolic and structural analysis of neuroimaging data. Thanks to high-quality MRI and very precise radiation delivery equipment which the team has at its disposal, hypofractionation has also been performed for tumors located close to critical brain structures. Under the leadership of Dr. Ivanov the Department has brought together a dedicated team of experienced and exceptionally qualified professionals. Being unbiased in their choice of treatment strategy and equipment, the team can provide the most beneficial care depending on the patient’s clinical situation. The paradigm of their work is perfect visualization followed by precise irradiation with no impairment of the unaffected brain.

Oral presentations at International conferences:

• ISRS Educational Course, 18 - 20 December 2023, Istanbul, Türkiye
  SRS/SRT in Management of Intracranial Metastases, Parenchymal Brain Tumors, Genitourinary, Gynecological, and Abdominal Cancers; Medical Physics and Imaging for Radiosurgery
  Oral presentasion: PET IMAGING FOR RADIOSURGERY
• The 2nd Sibereian-Serbian Neurosurgical Symposium,  December 11 – 12, Novosibirsk,
  Oral presentasion: MODERN TECHNIQUES OF STEREOTACTIC IRRADIATION IN NEUROSURGICAL PRACTICE
• ISRS Educational Course, 24 - 26 August 2023. Kochi, Kerala, India 
  SRS/SRT in Management of Benign Intracranial Tumors, Skull Base Tumors, and Abdominal, Genitourinary, and Gynecological Cancers; Modern Technologies for Radiosurgery.
  Oral presentasion: SRS/SRT IN VICINITY TO ANTERIOR OPTIC PATHWAYS.
• ISRS Educational Course, October 4 - 6, 2019 Tbilisi, Georgia 
  SRS/SRT IN MANAGEMENT OF INTRACRANIAL TUMORS, HEAD & NECK, LUNG AND ABDOMINAL CANCERS AND MEDICAL PHYSICS FOR RADIOSURGERY
  Oral presentasion: RADIOSURGICAL OPTIONS FOR LARGE BRAIN METASTASES.
• ISRS Educational Course, April 11 - 13, 2019 Debrecen, Hungary
  SRS/SRT IN MANAGEMENT OF MALIGNANT INTRACRANIAL TUMORS, LUNG, ABDOMINAL, AND PROSTATE CANCERS, AND MEDICAL PHYSICS FOR RADIOSURGERY
  Oral presentasion: RADIOSURGICAL OPTIONS FOR LARGE BRAIN METASTASES.
• ISRS Educational Course, November 1 - 3, 2018 Kuopio, Finland
  SRS/SRT IN MANAGEMENT OF BENIGN INTRACRANIAL TUMORS, CEREBROVASCULAR DISEASES, AND PROSTATE CANCER, MEDICAL PHYSICS FOR RADIOSURGERY
  Oral presentasion: SRS/SRT OF CRANIOPHARYNGIOMAS
• Primer simposio de la asociacion argentina de radiocirugia, 30-31 August 2018, Buenos Aires, Argentina.
  Oral presentasion: RADIOSURGERY OF BRAIN MALIGNANCIES: LIMITATIONS AND PERSPECTIVES.
• ISRS Educational Course, April 12 & 13, 2018 Kazan, Russia 
  SRS/SRT IN MANAGEMENT OF FUNCTIONAL BRAIN DISEASES, EYE PATHOLOGY, AND LUNG AND BREAST CANCERS. PEDIATRIC RADIOSURGERY
  Oral presentasion: GAMMA KNIFE SURGERY FOR UVEAL MELANOMA: POSSIBLE STRATEGIES AND TREATMENT TIPS.
• 19th Leksell Gamma Knife Society Meeting, March 4 - 8, 2018, Dubai, United Arab Emirates.
  Oral presentasion: GAMMA KNIFE RADIOSURGERY OF RADIORESISTANT BRAIN METASTASES: RADIOLOGICAL RESPONSE AND SURVIVAL OUTCOME.
• ISRS Educational Course, October 6 - 8, 2017 Sigulda, Latvia
  SRS/SRT IN MANAGEMENT OF INTRACRANIAL SCHWANNOMAS, SKULL BASE TUMORS, AND GENITO-URINARY CANCER
  Oral presentasion: SRS/SRT OF SKULL BASE MALIGNANCIES
• 13th  International Stereotactic Radiosurgery Society Congress, May 28 – June 1, 2017, Montreux, Switzerland
  Oral presentasion: HYPOFRACTIONATED STEREOTACTIC RADIOTHERAPY FOR THE TREATMENT OF BRAIN METASTASES: ANALYSIS OF 400 CASES.
• ISRS WEBINAR, February 28, 2017
  RADIOSURGERY OF UVEAL MELANOMA 
• The European Leksell Gamma Knife Society Meeting, Hamburg 25-27, November 2016
  Oral presentasion:  100 CASES OF HYPO-FRACTIONATION FOR RECURRENT MALIGNANT GLIAL TUMORS.
  Oral presentasion: 400 CASES OF HYPOFRACTIONATION FOR BRAIN METASTASES
• The 5th Russian-Japanese Neurosurgical Symposium, June 23-25, 2016, Kazan, Russia.
  Oral presentasion: TREATMENT OF LARGE BRAIN METASTASES: DO WE STILL NEED SURGERY?
• European Gamma Knife Society Meeting November 27-29,  2015, Marseille, France.
  Oral presentasion: IMPORTANT ASPECTS OF GAMMA KNIFE RADIOSURGERY FOR UVEAL MELANOMA
• 12th  International Stereotactic Radiosurgery Society Congress, June 7-11, 2015, Yokohama, Japan
  Oral presentasion: SIMULTANEOUS COMBINED STEREOTACTIC RADIATION TREATMENT OF BRAIN METASTASES USING GAMMA KNIFE, CYBER KNIFE AND TRUEBEAM STX.
  Oral presentasion: GAMMA KNIFE RADIOSURGERY IN THE EYE PRESERVING MANAGEMENT OF UVEAL MELANOMA
• 1st all-Russian conference on radiosurgery and stereotactic radiotherapy 21-22 May 2015, Moscow, Russia.
  Oral presentasion: RADIOSURGERY AND HYPOFRACTIONATION IN THE MANAGEMENT OF BRAIN METASTASES WITH COMBINED APPLICATION OF GAMMA KNIFE, CYBER KNIFE AND TRUEBEAM STX.
• World Leksell Gamma Knife Society Meeting, New York 12-16 May, 2014
  Oral presentasion: ANALYSIS OF OUTCOMES AFTER GAMMA KNIFE RADIOSURGERY FOR PATIENTS WITH MELANOMA BRAIN METASTASIS.
• 5th Annual Meeting of the Asian Gamma Knife Academy, St Petersburg, September 2011.
  Oral presentasion: MULTI-SESSION GAMMA-KNIFE RADIOSURGERY OF SCULL BASE CANCER.
• 2nd Japanese-Russian Neurosurgical Symposium, May 9-11, 2010, Fujikyu, Japan
  Oral presentasion: TELENEURORADIOLOGICAL TECHNOLOGIES IN RADIOSURGICAL PRACTICE. 

List of publications:

• Irina Zubatkina, PhD, Iuliana Toma-Dasu, PhD, Alexandru Dasu, PhD, Marc Levivier, MD, PhD, Constantin Tuleasca, MD, PhD, Pavel Ivanov, MD, PhD. Clinically Driven Alpha/Beta Ratios for Melanoma Brain Metastases and Investigation of Biologically Effective Dose as a Predictor for Local Control After Radiosurgery: A Proof of Concept in a Retrospective Longitudinal Series of 274 Consecutive Lesions Neurosurgery. 2024 Feb 1;94(2):423-430. doi: 10.1227/neu.0000000000002639. Epub 2023 Sep 4.
• Zubatkina I,  Ivanov P.  Early imaging radioresponsiveness of melanoma brain metastases as a predictor of patient prognosis. J Neurosurg. 2018 Aug; 129 (2): 354 - 365.
• Sinyavskiy O.A., Troyanovsky R.L., Ivanov P.I., Golovin A.S., Tibilov A.V., Solonina S.N., Astapenko A.M., Zubatkina I.S. Microinvasive tumor endoresection in combination with ocular stereotactic radiosurgery. J Neurosurg (Suppl 1) 125:58-63, 2016
• Zubatkina I., Ivanov P. Gamma Knife VIM Thalamotomy with Focus on Patient Selection, Targeting and Complications. Stereotact Funct Neurosurg 94 (suppl 1):64, 2016
• Ivanov P.,  Zubatkina I., Tumarova D., Andreev G., et al. Simultaneous combined stereotactic radiation treatment of brain metastases using Gamma Knife, Cyber Knife and TrueBeam STX. Journal of Radiosurgery and SBRT 3 (suppl 1):96, 2015
• Ivanov PI, Zubatkina IS, Tumarova DI, Andreev GI, Volkov NM. Analysis of results of Gamma Knife radiosurgery for patients with melanoma brain metastases. Vopr Onkol. 2015; 61 (4): 586 - 91.
• Zubatkina I, Ivanov P., Tumarova D., Andreev G. The influence of variations in radiological responses in melanoma brain metastases after GKR on patient prognosis. Journal of Radiosurgery and SBRT 3 (suppl 1):93, 2015
• Ivanov P., Sinyavskiy O., Boyko E., Troyanovsky R., Zubatkina I., Tumarova D., Golovin A. Gamma Knife Radiosurgery in the eye preserving management of uveal melanoma. Journal of Radiosurgery and SBRT 3 (suppl 1):158, 2015
• Guseĭnova Kh, Lishchak R, Shimonova G, Novotny J, Ivanov PI, Zubatkina IS, Plugar' IV, Golanov AV, Kostiuchenko VV.  Results of gamma-knife radiosurgery treatment for intracranial metastases of renal-cell cancer and prognostic factors influencing on the survival (joint study of three Eastern European Centers). Zh Vopr Neirokhir Im N N Burdenko. 2013; 77 (6): 4 - 12; discussion 13.Zh Vopr Neirokhir Im N N Burdenko. 2013. English, Russian.
• Chernov MF, Ono Y, Abe K, Usukura M, Hayashi M, Izawa M, Diment SV, Ivanov PI, Muragaki Y, Iseki H, Hori T, Okada Y, Takakura K. Differentiation of Tumor Progression and Radiation-Induced Effects after Intracranial Radiosurgery Acta Neurochir Suppl. 116: 193-210, 2013
• Hayashi M, Chernov MF, Tamura N, Izawa M, Muragaki Y, Iseki H, Okada Y, Ivanov P, Régis J, Takakura K. Concept of Robotic Gamma Knife Microradiosurgery and Results of Its Clinical Application in Benign Skull Base Tumors Acta Neurochir Suppl. 116:5-15, 2013
• Hayashi M, Chernov MF, Lipski SM, Tamura N, Yomo S, Horiba A, Tsuzuki S, Izawa M, Okada Y, Muragaki Y, Iseki H, Ivanov P, Régis J, Takakura K. Do We Really Still Need an Open Surgery for Treatment of Patients with Vestibular Schwannomas? Acta Neurochir Suppl. 116:25-36, 2013
• Hayashi M, Chernov MF, Tamura N, Yomo S, Tamura M, Horiba A, Izawa M, Muragaki Y, Iseki H, Okada Y, Ivanov P, Régis J, Takakura K. Usefulness of the Advanced Neuroimaging Protocol Based on Plain and Gadolinium-Enhanced Constructive Interference in Steady State Images for Gamma Knife Radiosurgery and Planning Microsurgical Procedures for Skull Base Tumors. Acta Neurochir Suppl. 116:167-78, 2013
• Hayashi M, Chernov M, Tamura N, Taira T, Izawa M, Yomo S, Nagai M, Chang CS, Ivanov P, Tamura M, Muragaki Y, Okada Y, Iseki H, Takakura K. Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system: technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment. Neurosurg Rev. 34(4):497-508, 2011
• Ivanov P, Chernov M, Hayashi M, Nakaya K, Izawa M, Murata N, Kubo O, Ujiie H, Muragaki Y, Nakamura R, Iseki H, Hori T, Takakura K: Low-dose gamma knife radiosurgery for cavernous sinus hemangioma: report of 3 cases and literature review. Minim Invasive Neurosurg 51: 140-146, 2008
• Chernov MF, Ivanov PI Urgent reoperation for major regional complications after removal of intracranial tumors: outcome and prognostic factors in 100 consecutive cases. Neurol Med Chir (Tokyo) 47: 243-249, 2007
• Chernov MF, Ivanov PI, Zhinzhina IV, Getmanova OY, Zabrodskaya JM, Tigliev GS: Complete recovery of visual functions after multimodality treatment for intrinsic chiasmatic-hypothalamic astrocytoma. Neurol Med Chir (Tokyo) 44: 129-132, 2004

Contacts: ivanov@ldc.ru, pavel.ivanov@mail.ru